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PURPOSE: Adenoid cystic carcinoma (ACC) of the trachea and bronchus is a rare tumor. Although MYB-NFIB oncogene fusion and Notch1 mutation have been identified in ACC, little is known about the expression and clinical significance of Notch1 and its target gene fatty acid binding protein 7 (FABP7) in tracheobronchial ACC. MATERIALS AND METHODS: Primary tracheobronchial ACC that were resected between 1998 and 2014 were identified through the pathology and oncology database from five thoracic oncology centers in China. A tissue array was constructed from the patients’ samples and the expressions of Notch1 and FABP7 were evaluated by immunohistochemistry. The association between the expression of both markers and survival was determined. RESULTS: Overexpression of Notch1 and FABP7, detected in 37.8% and 38.3% of 368 patients with tracheobronchial ACC, respectively, was an independent prognostic indicator for recurrencefree survival (RFS) by multivariable Cox proportional hazard model (p=0.032 and p=0.048, respectively). Overexpression of Notch1, but not of FABP7, predicted overall survival (OS) (p=0.018). When categorized into four groups according to coexpression of Notch1 and FABP7, patients with overexpression of both Notch1 and FABP7 belonged to the group with the shortest RFS and OS (p=0.01 and p=0.048, respectively). CONCLUSION: Expression of Notch1 and FABP7, and coexpression of Notch1 and FABP7, is strongly associated with poor survival in resected tracheobronchial ACC. These data are consistent with the hypothesis that poor differentiation of tracheobronchial ACC correlates with the activation of Notch signaling.
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Humans , Adenoids , Bronchi , Carcinoma, Adenoid Cystic , Carrier Proteins , China , Immunohistochemistry , Oncogene Fusion , Pathology , Prognosis , Proportional Hazards Models , Retrospective Studies , TracheaABSTRACT
Objective To build an evaluation index system for clinical research project outcomes for the purpose of timely monitoring of research projects,encouraging original research,clinical translation and outcome.Methods Questionnaire survey on prize-winning outcomes and projects completed to develop an initial index system; three rounds of experts consultation in Delphi method to produce the evaluation indexes and weights of these projects.Results We have built an index system comprising five class-1 indexes,ten class-2 indexes,and 29 class-3 indexes.Among such indexes,innovation and leading extent of the current research,R&D of IIPR of the product,and demands of research direction are key ones.Conclusion Evaluation of clinical research projects and the outcomes can monitor key indexes,guide and encourage science innovation and clinical translation.
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Clinical practice is an important part for medical students to become qualified doctors.The humanistic skill and medical operation skill training,test and evaluation before clinical practice are necessary.Results showed that the standard and routine training before clinical practice can help interns adapt to their practice life more easily.
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OBJECTIVE To probe into the impact factors of the nosocomial respiratory tract infections after the operations with tracheal intubation under general anesthesia in order to establish the prevention and treatment strategies and provide the scientific basis.METHODS By descriptive epidemiological method and case-control study method,80 cases with nosocomial respiratory tract infections in nearly 3 years who had tracheal intubation under general anesthesia were selected,and another 180 patients with non-nosocomial respiratory tract infections with tracheal intubation under general anesthesia were selected as the control.RESULTS The incidence of the nosocomial infections from 5923 patients of the operation with tracheal intubation under general anesthesia from 2005 to 2007 accounted for 10.1%.The incidence of the respiratory tract infections of operations under general anesthesia accounted for 5.25%.The nosocomial respiratory tract infection from the tracheal intubation under general anesthesia toped the list and accounted for 52.0%.It showed seven impact factors on the nosocomial respiratory tract infection after the operation with tracheal intubation under general anesthesia by the multi-factorial Logistic regression,respectively,with significant differences(P1).CONCLUSIONS There are many impact factors that the nosocomial respiratory tract infection(especially lower respiratory tract infection) resulting from the operation with tracheal intubation under general anesthesia.The study shows the main risk factors: age,the complications of the disease,surgical condition,the ventilation time of tracheal intubationunder the anesthesia,post-operative recovery time,smoking status,the time that the operated patients start coughing after the operation.Therefore,the prevention is especially important.
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Objective:To learn the mental health state of the Guangzhou medical students.Method:Symptom Check List 90(SCL-90) was selected to investigate 605 medical students in Guangzhou Medical College from the first year to the fifth year by stratified cluster sampling.The results were compared with the three regular models of the country.Conclusion:The mental health of the Guangzhou medical students is a little worse than that of the regular model of the adult in the country but is better than that of the regular models of the youth and the college students in the country.(except the body symptom)